Role of the aryl hydrocarbon receptor in cell cycle regulation
| Autor: | Xaoqing Chang, Sonya J. Barnes, Matt Strobeck, J. Kevin Kerzee, Zongqing Tan, Alvaro Puga, Erik S. Knudsen, Jennifer Marlowe, Ching-Yi Chang, Andrew Maier |
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| Rok vydání: | 2002 |
| Předmět: |
DNA Replication
Cell cycle checkpoint biology Cell growth Cell Cycle Cytochrome a Group Aromatic hydrocarbon receptor Apoptosis Cell cycle Toxicology Aryl hydrocarbon receptor Ligands Retinoblastoma Protein Biochemistry Receptors Aryl Hydrocarbon biology.protein Animals Humans Environmental Pollutants Signal transduction Polycyclic Aromatic Hydrocarbons E2F Transcription factor Plasmids |
| Zdroj: | Toxicology. |
| ISSN: | 0300-483X |
| Popis: | One of the most puzzling aspects of the biological impact of polycyclic aromatic hydrocarbon compounds is that they elicit an apparently unrelated variety of toxic, teratogenic, and carcinogenic responses in exposed animals and in humans. At the cellular level, these environmental toxicants affect cell cycle regulatory mechanisms and signal transduction pathways in ways that are equally diverse and often contradictory. For example, depending on the particular cell lines studied, exposure to these compounds may lead to cell proliferation, to terminal differentiation, or to apoptosis. These effects are mediated by the aryl hydrocarbon receptor, a ligand-activated transcription factor well known for its regulatory activity on the expression of several phase I detoxification cytochrome P450 genes. Research into the molecular mechanisms of aryl hydrocarbon receptor function has uncovered a novel role for this protein during cell cycle progression. The activated receptor acts as an environmental sensor and cell cycle checkpoint that commits cells exposed to adverse environmental stimuli to arrest before the onset of DNA replication. |
| Databáze: | OpenAIRE |
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