Intranasal BDNF administration promotes visual function recovery in adult amblyopic rats
| Autor: | Alessandro Sale, Gabriele Sansevero, Laura Baroncelli, Manuela Scali |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Visual acuity genetic structures Tropomyosin receptor kinase B Amblyopia Ocular dominance 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neuroplasticity medicine Animals Receptor trkB Rats Long-Evans Administration Intranasal Vision Ocular Visual Cortex Pharmacology Brain-derived neurotrophic factor Depth Perception Environmental enrichment Neuronal Plasticity business.industry Brain-Derived Neurotrophic Factor Recovery of Function eye diseases 030104 developmental biology Visual cortex medicine.anatomical_structure Female Visual depth perception Sensory Deprivation medicine.symptom business Neuroscience 030217 neurology & neurosurgery Central Nervous System Agents |
| Zdroj: | Neuropharmacology. 145:114-122 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2018.02.006 |
| Popis: | Amblyopia is the most common cause of visual impairment in one eye, with a prevalence of 1-5% in the world population. While amblyopia can be efficiently treated in children, it becomes irreversible in adults, due to the decline in neural plasticity past the end of the visual cortex critical period. Accordingly, no pharmacological approaches are available to rescue visual functions in adult amblyopic subjects. We report that non-invasive intranasal infusion of BDNF increased levels of this neurotrophic factor in V1 and induced a recovery of visual acuity, ocular dominance and visual depth perception in adult amblyopic rats, both in reverse-occluded animals and in those with unrestricted binocular sight. Visual recovery was long-lasting, and was prevented by pharmacological blockade of TrkB signaling in the visual cortex. These results underscore the possibility to replace invasive BDNF central administration with a safe procedure of potential interest in a number of currently still cureless central nervous system pathologies. This article is part of the Special Issue entitled "Neurobiology of Environmental Enrichment". |
| Databáze: | OpenAIRE |
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