Cross-Reactive Epitope among Proteins in Plasmodium falciparum Maurer's Clefts and Primate Leukocytes and Platelets
| Autor: | Russell J. Howard, Szarfman A, Masamichi Aikawa, F W Klotz, Cohen Sj |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Erythrocytes
Pan troglodytes medicine.drug_class Plasmodium falciparum Antigens Protozoan Cross Reactions Monoclonal antibody Plasmodium Epitope Epitopes Mice Species Specificity Antigen Virology parasitic diseases Leukocytes medicine Animals Humans Platelet Malaria Falciparum biology Autoantibody Antibodies Monoclonal biology.organism_classification Antigens Differentiation Molecular biology In vitro Infectious Diseases Liver Parasitology |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 54:655-659 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Erythrocytes infected with malaria parasites often contain membranous vesicles that are presumed to facilitate macromolecule traffic between the parasite and erythrocyte membranes. One such vesicle network, called Maurer's clefts, is expressed in Plasmodium falciparum-infected erythrocytes and contains a 50-kD polypeptide. Using a monoclonal antibody reactive with this polypeptide, we show that hepatic stages of P. falciparum express an epitope common to this blood-stage antigen. In addition, this epitope is cross-reactive with antigens expressed by primate leukocytes and platelets. Such epitopes may induce autoantibodies commonly seen in patients with malaria. |
| Databáze: | OpenAIRE |
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