Anatomic characterization of prelemniscal radiations by probabilistic tractography: implications in Parkinson's disease
| Autor: | Luis Concha, Maria Guadalupe García-Gomar, Francisco Velasco-Campos, Julián Eduardo Soto-Abraham |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cerebellum Histology Deep brain stimulation medicine.medical_treatment computer.software_genre 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Voxel Subthalamic Nucleus Neural Pathways medicine Image Processing Computer-Assisted Humans General Neuroscience Motor control Brain Parkinson Disease Anatomy Middle Aged White Matter Subthalamic nucleus Globus pallidus medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Female Psychology computer Neuroscience 030217 neurology & neurosurgery Tractography |
| Zdroj: | Brain structurefunction. 222(1) |
| ISSN: | 1863-2661 |
| Popis: | To characterize the anatomical connectivity of the prelemniscal radiations (Raprl), a white matter region within the posterior subthalamic area (PSA) that is an effective neurosurgical target for treating motor symptoms of Parkinson's disease (PD). Diffusion-weighted images were acquired from twelve healthy subjects using a 3T scanner. Constrained spherical deconvolution, a method that allows the distinction of crossing fibers within a voxel, was used to compute track-density images with sufficient resolution to accurately delineate distinct PSA regions and probabilistic tractography of Raprl in both hemispheres. Raprl connectivity was reproducible across all subjects and showed fibers traversing through this region towards primary and supplementary motor cortices, the orbitofrontal cortex, ventrolateral thalamus, and the globus pallidus, cerebellum and dorsal brainstem. All brain regions reached by Raprl fibers are part of motor circuits involved in the pathophysiology of PD; while these fiber systems converge at the level of the PSA, they can be spatially segregated. Fibers of distinct and specific motor control networks are identified within Raprl. The description of this anatomical crossroad suggests that, in the future, tractography could allow deep brain stimulation or lesional therapies in white matter targets according to individual patient's symptoms. |
| Databáze: | OpenAIRE |
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