Glucose effectiveness and insulin sensitivity measurements derived from the non-insulin-assisted minimal model and the clamp techniques are concordant
| Autor: | Henning Beck-Nielsen, Frank P. Alford, Glenn M. Ward, Jan Erik Henriksen, Raymond C. Boston, Peter Thye-Rønn, Ole Hother-Nielsen, Klaus Levin, Christian Rantzau |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Euglycaemic hyperinsulinaemic clamp Young Adult Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Insulin Pancreatic hormone business.industry Insulin sensitivity Glucose Tolerance Test medicine.disease Glucose Clamp Diabetes Mellitus Type 2 Basal (medicine) Glucose Clamp Technique Female Insulin Resistance Whole body business |
| Zdroj: | Henriksen, J E, Alford, F, Ward, G, Thye-Rønn, P, Levin, K, Hother-Nielsen, O, Rantzau, C, Boston, R & Beck-Nielsen, H 2010, ' Glucose effectiveness and insulin sensitivity measurements derived from the non-insulin-assisted minimal model and the clamp techniques are concordant ', Diabetes-Metabolism: Research and Reviews (Print Edition), vol. 26, no. 7, pp. 569-78 . https://doi.org/10.1002/dmrr.1127 |
| ISSN: | 1520-7552 |
| Popis: | Background We investigated the concordance between glucose effectiveness (SG) and insulin sensitivity (SI), derived from the unmodified dynamic non-insulin-assisted intravenous glucose tolerance test (IVGTT) implemented by SGMM and SIMM; simulation analysis and modelling/conversational interaction (SAAM/CONSAM) versus the eu/hyperglycaemic basal insulinaemic and the euglycaemic hyperinsulinaemic clamp (SGCLAMP and SICLAMP). Methods Twenty-seven of 30 normoglycaemic subjects completed a (1) euglycaemic hyperinsulinaemic clamp, (2) 6-h eu/hyperglycaemic near-normoinsulinaemic pancreatic clamp with hyperglycaemia present over the final 2 h of the clamp (Day 2 study), (3) identical clamp to (2) but with euglycaemia maintained over the entire 6 h (Day 3 study) and (4) IVGTT. SGCLAMP was calculated in two ways based on data from study (2) alone (Day 2 SGCLAMP210–240′) or from data from study day (2) and (3) (Day 2–3 SGCLAMP330–360′). Results SGMM was unrelated to the magnitude of endogenous insulin release (AIR). The single-day (Day 2) and two-day (Day 2 and 3) SGCLAMP protocols correlated (r = 0.72, p = 0.003), but SGCLAMP210–240′ was significantly (p = 0.001) higher than SGCLAMP330–360′. Employing the Day 2 and 3 SGCLAMP protocol, the whole body SGCLAMP330–360′ was similar to SGMM (1.80 ± 0.82 versus 1.73 ± 0.58 dL/min) and correlated (r = 0.45, p < 0.02). SGCLAMP210–240′ did not correlate with SGMM (r = 0.24). SIMM and SICLAMP were similar (0.093 ± 0.060 versus 0.087 ± 0.029 dL/min per mU/L) and correlated (r = 0.76, p < 0.001). Conclusions The time-dependent increase in glucose disposal observed during a prolonged 6-h clamp significantly influences the estimation of SGCLAMP, and significant concordance coefficients are observed between SGMM, and SGCLAMP330–360′, and SIMM and SICLAMP. Copyright © 2010 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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