The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma
| Autor: | Leanne C. Huysentruyt, Michael S. McGrath |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
reservoir
AIDS-Related Non-Hodgkin Lymphoma Immunology Population HIV Core Protein p24 Reviews HIV Infections Biology 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans metastasis cancer Immunology and Allergy Macrophage Neoplasm Metastasis education Lymphoma AIDS-Related 030304 developmental biology 0303 health sciences education.field_of_study Chemotactic Factors Macrophages HIV virus diseases Cancer Cell Biology medicine.disease 3. Good health Lymphoma Non-Hodgkin's lymphoma Tumor progression 030220 oncology & carcinogenesis |
| Zdroj: | Journal of Leukocyte Biology |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0809564 |
| Popis: | Review of the potential role of macrophage viral reservoirs in AIDS-related lymphoma development and metastasis by focusing on the possibility that HIV creates pathogenic environments. Despite HAART, patients infected with HIV develop NHL at a significantly higher level than the noninfected population. The primary difference between lymphoma in non-HIV-infected individuals and those with ARL is that ARL is consistently high-grade and metastatic. The emergence of ARL is associated with the presence of macrophage viral reservoirs, similar to what has been observed for HAD. HIV-infected macrophages, as seen by histology and HIV p24 staining, are present in approximately half of ARLs. Macrophage reservoirs recruit additional immune cells, including monocytes/macrophages, through the release of chemoattractants. Additionally, TAM are known to promote tumor progression for most cancer types, including lymphomas. This review will highlight and discuss the role of macrophage viral reservoirs in the development and progression of ARLs and hopefully, shed light on this new and interesting field. |
| Databáze: | OpenAIRE |
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