Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection
| Autor: | Carlos Lumbreras, Jaime Lora-Tamayo, Irene Losada, Octavio Carretero, José María Aguado, Rafael San Juan, Mikel Mancheño-Losa, Estibaliz Arrieta, Antonio Lalueza, A. García-Reyne, Guillermo Maestro de la Calle, Mario Fernández-Ruiz, Cristina de la Calle, Raquel Díaz-Simón, Borja de Miguel, Francisco López-Medrano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Hospitalized patients Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 030106 microbiology Disease Real-Time Polymerase Chain Reaction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Disease severity Nasopharynx Internal medicine Lactate dehydrogenase medicine Humans 030212 general & internal medicine Aged Aged 80 and over business.industry COVID-19 General Medicine Middle Aged Viral Load Hospitalization Infectious Diseases Respiratory failure chemistry COVID-19 Nucleic Acid Testing Population study Female Original Article Respiratory Insufficiency business Viral load |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-020-04150-w |
| Popis: | The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity. All hospitalized adult patients with a diagnosis of SARS-CoV-2 infection by rRT-PCR performed on a nasopharingeal sample from March 1 to March 18 in our institution were included. The study population was divided according to the Ct value obtained upon admission in patients with high viral load (Ct 30). Demographic, clinical and laboratory variables of the different groups were analyzed to assess the influence of viral load on the development of respiratory failure during admission. Overall, 455 sequential patients were included. The median Ct value was 28 (IQR: 24–32). One hundred and thirty patients (28.6%) had a high viral load, 175 (38.5%) an intermediate viral load and 150 (33%) a low viral load. Advanced age, male sex, presence of cardiovascular disease and laboratory markers such as lactate dehydrogenase, lymphocyte count and C-reactive protein, as well as a high viral load on admission, were predictive of respiratory failure. A Ct value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink