IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections
| Autor: | Andy Croxford, Vanja Lazarevic, Amit Awasthi, Brian S. Wilson, Vijay K. Kuchroo, Lorena Riol-Blanco, Meike Mitsdoerffer, Mohamed Oukka, Ari Waisman, Laurie H. Glimcher |
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| Rok vydání: | 2010 |
| Předmět: |
T cell
CD8 Antigens Receptors Antigen T-Cell alpha-beta Immunology Mice Nude Mice Transgenic Biology Article Immunophenotyping Interferon-gamma Mice Immune system Antigen Cell Movement T-Lymphocyte Subsets medicine Immunology and Allergy Animals Interferon gamma Listeriosis Cells Cultured Mice Knockout Effector Tumor Necrosis Factor-alpha Intracellular parasite Interleukin-17 Receptors Antigen T-Cell gamma-delta Receptors Interleukin Coculture Techniques Cell biology medicine.anatomical_structure CD4 Antigens Interleukin-23 Subunit p19 Tumor necrosis factor alpha Interleukin 17 Peritoneum medicine.drug |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 184(4) |
| ISSN: | 1550-6606 |
| Popis: | IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of γδ and double negative (DN) αβ T cells. These cells were rapidly recruited to the site of infection and produced large amounts of IL-17, IFN-γ, and TNF-α. Notably, DN T cells transferred into L. monocytogenes-infected RAG2−/− mice prevented bacterial growth, confirming their protective role against intracellular pathogens. Our results show that IL-23 regulates the function of IL-17–producing γδ and DN T cells, two essential components of the early protective immune response directed against intracellular pathogens. |
| Databáze: | OpenAIRE |
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