Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease

Autor: Grace C.A. Manley, Yongliang Zhang, Lisa C. Parker
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
MAPK/ERK pathway
T-Lymphocytes
Review
Pathogenesis
lcsh:Chemistry
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
lcsh:QH301-705.5
Spectroscopy
COPD
RSV
General Medicine
respiratory system
Computer Science Applications
medicine.anatomical_structure
rhinovirus
Virus Diseases
030220 oncology & carcinogenesis
Cytokines
Dual-Specificity Phosphatases
medicine.symptom
influenza
MAP Kinase Signaling System
T cell
Inflammation
Respiratory Mucosa
Catalysis
Inorganic Chemistry
03 medical and health sciences
respiratory viruses
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
business.industry
Organic Chemistry
Airway obstruction
asthma
medicine.disease
Respiration Disorders
MAPK
respiratory tract diseases
030104 developmental biology
Viral replication
lcsh:Biology (General)
lcsh:QD1-999
Immunology
business
Airway
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 3, p 678 (2019)
ISSN: 1422-0067
Popis: Inflammatory airway disease, such as asthma and chronic obstructive pulmonary disease (COPD), is a major health burden worldwide. These diseases cause large numbers of deaths each year due to airway obstruction, which is exacerbated by respiratory viral infection. The inflammatory response in the airway is mediated in part through the MAPK pathways: p38, JNK and ERK. These pathways also have roles in interferon production, viral replication, mucus production, and T cell responses, all of which are important processes in inflammatory airway disease. Dual-specificity phosphatases (DUSPs) are known to regulate the MAPKs, and roles for this family of proteins in the pathogenesis of airway disease are emerging. This review summarizes the function of DUSPs in regulation of cytokine expression, mucin production, and viral replication in the airway. The central role of DUSPs in T cell responses, including T cell activation, differentiation, and proliferation, will also be highlighted. In addition, the importance of this protein family in the lung, and the necessity of further investigation into their roles in airway disease, will be discussed.
Databáze: OpenAIRE
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