Platelet Activation Through the Efficacy of Aspirin in Congenital Heart Disease Patients Undergoing Transcatheter Closure of Atrial Septal Defects or Ventricular Septal Defects
| Autor: | Gang Pan, Zhi-Wei Zhang, Ying Zhang, Sheng-Chun Long, Zhao-Feng Xie, Xi-Ping Xu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Heart Septal Defects Ventricular Male Cardiac Catheterization medicine.medical_specialty Time Factors Percutaneous Adolescent Platelet Aggregation Heart disease Heart Septal Defects Atrial Atrial septal defects Internal medicine Occlusion medicine Humans Platelet Platelet activation Genetics (clinical) Aspirin business.industry General Medicine medicine.disease Surgery P-Selectin Catheter Cardiology Female business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 18:832-838 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2014.0206 |
| Popis: | The aim of this study is to compare preoperative and postoperative conditions of GMP-140 concentration, the aggregation and activation of platelets in congenital heart disease patients undergoing transcatheter closure of atrial septal defects (ASDs) or ventricular septal defects (VSDs), and the appropriate dose of aspirin of patients after transcatheter closure.Thirty-two consecutive patients with ASD (n=16) and VSD (n=16), as shown on transthoracic echocardiography and right heart catheter examination, were treated with a percutaneous catheter occlusion. The patients comprised 13 males and 19 females with a mean age of 25.6±9.15. Patients were randomly assigned into two groups within half an hour after ASD or VSD occlusion. Group A cases were treated with 3 mg/kg/day enteric-coated aspirin tablets for 6 months, while patients in group B received 5 mg/kg/day enteric-coated aspirin tablets for 6 months.The rates of platelet aggregation (PAG) in the immediate postoperative ASD/VSD occlusion were significantly higher than those in the preoperative ASD/VSD occlusion (adenosine diphosphate [ADP]-induced PAG: 64.98%±7.65% vs. 86.33%±6.54%, p0.05; arachidonic acid [AA]-induced PAG: 62.92%±9.11% vs. 86.96%±6.90%, p0.05, respectively). After treatment with aspirin, the GMP-140 levels presented a clearly defined downward trend in the immediate postoperative period (3 mg/kg/day aspirin: 18.30±3.42 vs. 13.37±1.80, p0.05; 5 mg/kg/day aspirin: 18.30±3.42 vs. 13.41±1.60, p0.05), but no obvious difference was observed considering the GMP-140 levels in the 4 days after occlusion (all p0.05).Our study showed that the GMP-140 serum level and PAG were increased after ASD and VSD occlusion, and patients may have a trend of decreased GMP-140 serum levels after the ASD or VSD occlusion surgeries after the treatment with aspirin. Daily oral administration of 3 and 5 mg/kg/day aspirin can induce a significant decrease in PAG of patients after VSD/ASD occlusion. |
| Databáze: | OpenAIRE |
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