Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock
| Autor: | Wilson Mena, François Rouyer, Abhishek Chatterjee, Patrick Emery, Béatrice Martin, Angélique Lamaze, Elisabeth Chélot, Sebastian Kadener, Paul E. Hardin, Joydeep De |
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| Přispěvatelé: | Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Biology and Center for Biological Clocks Research, Brandeis University, University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Circadian clock Synchronizing Context (language use) Biology Article General Biochemistry Genetics and Molecular Biology morning and evening oscillators 03 medical and health sciences Pigment dispersing factor Circadian Clocks circadian clock Biological neural network Animals Circadian rhythm hormone receptor-like in 38 Sensory cue Neurons [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Brain [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Circadian Rhythm Coupling (electronics) rest-activity rhythms Drosophila melanogaster 030104 developmental biology pigment-dispersing factor visual system Drosophila General Agricultural and Biological Sciences light Neuroscience posterior dorsal neurons 1 oscillator coupling |
| Zdroj: | Current Biology-CB Current Biology-CB, Elsevier, 2018, ⟨10.1016/j.cub.2018.04.064⟩ |
| ISSN: | 0960-9822 1879-0445 |
| DOI: | 10.1016/j.cub.2018.04.064⟩ |
| Popis: | International audience; The brain clock that drives circadian rhythms of locomotor activity relies on a multi-oscillator neuronal network. In addition to synchronizing the clock with day-night cycles, light also reformats the clock-driven daily activity pattern. How changes in lighting conditions modify the contribution of the different oscillators to remodel the daily activity pattern remains largely unknown. Our data in Drosophila indicate that light readjusts the interactions between oscillators through two different modes. We show that a morning s-LNv > DN1p circuit works in series, whereas two parallel evening circuits are contributed by LNds and other DN1ps. Based on the photic context, the master pacemaker in the s-LNv neurons swaps its enslaved partner-oscillator-LNd in the presence of light or DN1p in the absence of light-to always link up with the most influential phase-determining oscillator. When exposure to light further increases, the light-activated LNd pacemaker becomes independent by decoupling from the s-LNvs. The calibration of coupling by light is layered on a clock-independent network interaction wherein light upregulates the expression of the PDF neuropeptide in the s-LNvs, which inhibits the behavioral output of the DN1p evening oscillator. Thus, light modifies inter-oscillator coupling and clock-independent output-gating to achieve flexibility in the network. It is likely that the light-induced changes in the Drosophila brain circadian network could reveal general principles of adapting to varying environmental cues in any neuronal multi-oscillator system. |
| Databáze: | OpenAIRE |
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