Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery
| Autor: | Wei Xue, Ying Miao, Thomas Brett Kirk, Zhang Jieling, Wang Yongzhou, Dong Ma, Jianping Wu, Jiake Xu |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Light Biocompatibility Alginates Cell Survival Biocompatible Materials Bioengineering Poloxamer 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Mice Glucuronic Acid Tissue engineering Animals Elastic modulus Drug Carriers Hexuronic Acids technology industry and agriculture Hydrogels 3T3 Cells 021001 nanoscience & nanotechnology Macromonomer 0104 chemical sciences Drug Liberation Methotrexate Mechanics of Materials Printing Three-Dimensional Self-healing hydrogels Drug delivery Ink Rheology 0210 nano-technology Drug carrier Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 84:44-51 |
| ISSN: | 0928-4931 |
| Popis: | Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional (3D) printing technology to fabricate the shape memory hydrogels with internal structure (SMHs) by combining sodium alginate (alginate) and pluronic F127 diacrylate macromer (F127DA). SMHs were constituted by a dual network structure. One is a stable network which is formed by F127DA photo-crosslinking; the other one is a reversible network which is formed by Ca2+ cross-linked alginate. SMHs recovery ratio was 98.15% in 10min after Ca2+ was removed in the Na2CO3 solution, and the elastic modulus remains essentially stable after the shape memory cycle. It showed that the drug releasing rate is more rapid compared with traditional drug-loaded hydrogels in in vitro experiments. The viability of 3T3 fibroblasts remained intact which revealed its excellent biocompatibility. Therefore, SMHs have a huge prospect for application in drug carriers and tissue engineering scaffold. |
| Databáze: | OpenAIRE |
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