Comparative analysis of genomic inbreeding parameters and runs of homozygosity islands in several fancy and meat rabbit breeds

Autor:	Mohamad Ballan, Giuseppina Schiavo, Samuele Bovo, Michele Schiavitto, Riccardo Negrini, Andrea Frabetti, Daniela Fornasini, Luca Fontanesi
Přispěvatelé:	Ballan, Mohamad, Schiavo, Giuseppina, Bovo, Samuele, Schiavitto, Michele, Negrini, Riccardo, Frabetti, Andrea, Fornasini, Daniela, Fontanesi, Luca
Rok vydání:	2022
Předmět:	Islands Meat Genotype Homozygote ROH SNP Genomics General Medicine Polymorphism Single Nucleotide Oryctolagus cuniculu signature of selection genetic variability Genetics Animals Inbreeding Animal Science and Zoology Rabbits
Zdroj:	Animal Genetics. 53:849-862
ISSN:	1365-2052 0268-9146
DOI:	10.1111/age.13264
Popis:	Runs of homozygosity (ROH) are defined as long stretches of DNA homozygous at each polymorphic position. The proportion of genome covered by ROH and their length are indicators of the level and origin of inbreeding. In this study, we analysed SNP chip datasets (obtained using the Axiom OrcunSNP Array) of a total of 702 rabbits from 12 fancy breeds and four meat breeds to identify ROH with different approaches and calculate several genomic inbreeding parameters. The highest average number of ROH per animal was detected in Belgian Hare (~150) and the lowest in Italian Silver (~106). The average length of ROH ranged from 4.001 ± 0.556Mb in Italian White to 6.268 ± 1.355Mb in Ermine. The same two breeds had the lowest (427.9 ± 86.4 Mb, Italian White) and the highest (921.3 ± 179.8 Mb, Ermine) average values of the sum of all ROH segments. More fancy breeds had a higher level of genomic inbreeding (as defined by ROH) than meat breeds. Several ROH islands contain genes involved in body size, body length, pigmentation processes, carcass traits, growth, and reproduction traits (e.g.: AOX1, GPX5, IFRD1, ITGB8, NELL1, NR3C1, OCA2, TRIB1, TRIB2). Genomic inbreeding parameters can be useful to overcome the lack of information in the management of rabbit genetic resources. ROH provided information to understand, to some extent, the genetic history of rabbit breeds and to identify signatures of selection in the rabbit genome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dadf3a85e466c315f5cd06878d52b0a https://doi.org/10.1111/age.13264 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.