Components of variance for vibratory and thermal threshold testing in normal and diabetic subjects
| Autor: | Rex S. Clements, Douglas A. Greene, Joseph C. Arezzo, Edward W. Munster, David A. Gelber, Harry Shamoon, Daniel Porte, Adina Zeidler, Vera Bril, Michael A. Pfeifer, Michael J. Peterson, Charles Laudadio, Vasti L. Broadstone |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Hot Temperature Diabetic neuropathy Adolescent Endocrinology Diabetes and Metabolism Coefficient of variation Sensitivity and Specificity Vibration Cohort Studies Endocrinology Diabetic Neuropathies Reference Values Physical Stimulation Diabetes mellitus Internal medicine Sensory threshold Diabetes Mellitus Internal Medicine medicine Humans Aged Analysis of Variance Reproducibility business.industry Age Factors Reproducibility of Results Middle Aged medicine.disease Surgery Cold Temperature Peripheral neuropathy Sensory Thresholds Cardiology Analysis of variance Nerve conduction business Algorithms |
| Zdroj: | Journal of Diabetes and its Complications. 9:170-176 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/1056-8727(94)00042-m |
| Popis: | Quantitative sensory testing (QST) is commonly used in the assessment of diabetic neuropathy. However, little data are available on the reliability of tactile and thermal testing devices. Reproducibility of QST measures between centers has not been previously reported. This study was designed to validate QST testing procedures and determine if these devices are suitable for large scale multicenter clinical trials. Finger and toe vibratory (Vf, Vt) and thermal (Tf, Tt) thresholds were determined for ten normal individuals by a two-alternative forced-choice procedure using the Optacon Tactile Tester (OTT) and Thermal Sensitivity Tester (TST). Threshold measurements were reproducible between technologists and had a day-to-day coefficient of variation of Vf 20%, Vt 23%, Tf 41%, and Tt 95%. Thresholds were determined for 140 normal individuals at six centers. Mean threshold values between centers were not significantly different. Center-to-center coefficients of variation (CV) were Vf 44%, Vt 45%, Tf 47%, and Tt 87%. There was no significant difference in threshold measures with regard to sex, side studied, presence of calluses, or skin temperature. Vf thresholds significantly correlated with age (p < 0.01). There was no correlation between either vibratory or thermal thresholds in normal individuals, and nerve conduction velocities (NCV). Thermal and vibratory thresholds were determined for 98 diabetic patients. Diabetic subjects without clinical evidence of neuropathy were not significantly different from normal individuals, but diabetic patients with neuropathy had increased thresholds compared to normals (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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