The Influence of Bicarbonate/Lactate-Buffered PD Fluids on Nε-(Carboxyethyl)Lysine and Nε-(Carboxymethyl)Lysine in Peritoneal Effluent

Autor: Trijntje T. Cnossen, Jeroen P. Kooman, Karin Moret, Ulrich Gladziwa, Casper G. Schalkwijk, Jos J. van de Kerkhof, Jean L.J.M. Scheijen, Jolanda van Amersfoort, Charles H. Beerenhout
Přispěvatelé: RS: NUTRIM - R1 - Metabolic Syndrome, Interne Geneeskunde, RS: CARIM School for Cardiovascular Diseases
Rok vydání: 2011
Předmět:
Glycation End Products
Advanced
Male
N-epsilon-(carboxymethyl)lysine (CML)
medicine.medical_specialty
PROTEINS
Bicarbonate
medicine.medical_treatment
Lysine
030232 urology & nephrology
Peritonitis
PRODUCT
Peritoneal dialysis
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
Ne carboxymethyl lysine
AGE
0302 clinical medicine
Glycation
Internal medicine
medicine
Ascitic Fluid
Humans
Prospective Studies
030212 general & internal medicine
Effluent
UREMIA
Dose-Response Relationship
Drug
Chemistry
DIALYSIS SOLUTIONS
General Medicine
Middle Aged
N-epsilon-(carboxyethyl)lysine (CEL)
residual renal function
Lactic acid
Bicarbonates
Endocrinology
Biochemistry
Nephrology
Lactates
Kidney Failure
Chronic
Female
Peritoneum
Peritoneal Dialysis
advanced glycation end products (AGE)
Follow-Up Studies
Zdroj: Peritoneal Dialysis International, 31(2), 189-193. Multimed Inc.
ISSN: 1718-4304
0896-8608
DOI: 10.3747/pdi.2010.00009
Popis: ObjectiveAccumulation of advanced glycation end products (AGEs) may be involved in the pathogenesis of peritoneal membrane dysfunction. As glycoxidation may play an important role in AGE formation, peritoneal dialysis fluids with low levels of glucose degradation products (GDPs) might result in a reduction in AGE concentration in the peritoneal effluent. The aim of this study was to compare the effects of conventional glucose-containing dialysis solutions and low GDP level fluids on the concentration of the AGEs Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) in peritoneal effluent.DesignProspective randomized control study.Methods23 patients were treated with either conventional glucose-containing fluid ( n = 11, group A) or low level GDP fluid ( n = 12, group B) during a period of 12 weeks. Before and after this period, CML and CEL were measured in peritoneal effluent.ResultsIn groups A and B there were changes in CML concentrations [respectively 13.7 ± 17.0 and -16.0 ± 46.0 nmol/L (NS)] and CEL concentrations (respectively 20.3 ± 26.6 and -8.8 ± 18.9 nmol/L, p = 0.015). Residual renal function (RRF) in groups A and B was, respectively, 6.8 and 6.1 mL/min (NS). CML, but not CEL, in the peritoneal effluent was inversely related to RRF ( r = -0.67, p < 0.05).ConclusionCEL, but not CML, in the peritoneal effluent appears to be influenced by the prescription of low GDP level fluid, probably due to the highly reduced concentration of methylglyoxal, which is needed for formation of CEL. CML is primarily influenced by RRF.
Databáze: OpenAIRE
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