Involvement of Interleukin-18 in Patients on Maintenance Haemodialysis
| Autor: | Agostino Mallamace, Domenico Santoro, Vincenzo Savica, Rosaria Alba Merendino, Paola Lucia Minciullo, Sebastiano Gangemi, Guido Bellinghieri |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_treatment Renal Dialysis medicine Humans In patient skin and connective tissue diseases Dialysis Immunodeficiency Aged business.industry Interleukin-18 T-Lymphocytes Helper-Inducer Middle Aged medicine.disease Cytokine Nephrology Kt/V Immunology Interleukin 12 Kidney Failure Chronic Female Interleukin 18 sense organs Hemodialysis business |
| Zdroj: | American Journal of Nephrology. 22:417-421 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000065269 |
| Popis: | Maintenance dialysis induces a clinical state of immunodeficiency. The pathway of circulating T cells from haemodialyzed patients is changed and characterized by an increase of Th1 cells. The unbalanced T helper differentiation derives from an altered regulation of interleukin-12 (IL-12), which represents an important inducer of Th1. IL-18 is a pro-inflammatory cytokine expressed by a variety of cell types that is structurally related to the Th1 family and shares biological properties with IL-12 as the promotion of Th1 responses. To explain the involvement of IL-18 in the typical disorders of dialysis, we analyzed IL-18 serum levels in a group of haemodialyzed patients. We enrolled 16 patients on chronic haemodialysis (HD) treatment for end-stage renal failure and 16 healthy volunteers as the control group. IL-18 levels were assessed by immunoenzymatic methods (detection limit was |
| Databáze: | OpenAIRE |
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