Usefulness of intraventricular infusion of antifungal drugs through Ommaya reservoirs for cryptococcal meningitis treatment
| Autor: | En Kimura, Tomoo Hirahara, Shoji Honda, Jun Ichi Kuratsu, Shigetoshi Yano, Yukio Ando, Masaki Watanabe, Tatsuya Nakama, Makoto Uchino, Sadahisa Okamoto, Satoshi Yamashita |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Antifungal Agents Nausea media_common.quotation_subject Fosfluconazole Meningitis Cryptococcal Drug Delivery Systems Amphotericin B medicine Ommaya reservoir Humans Adverse effect Aged Retrospective Studies media_common Aged 80 and over Voriconazole business.industry Middle Aged Surgery Treatment Outcome Neurology Female Neurology (clinical) medicine.symptom business Fluconazole medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 358:259-262 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2015.09.005 |
| Popis: | Introduction Cryptococcal meningitis is a severe infection among immunosuppressed individuals, with a high mortality rate. Although amphotericin B is the first-choice drug for treatment, its use is restricted when adverse effects are clinically problematic. The usefulness of intraventricular infusion of antifungal drugs through Ommaya reservoirs for cryptococcal meningitis treatment has been unconfirmed. We evaluated the efficacy of intraventricular infusion of amphotericin B through Ommaya reservoirs. Materials and methods We retrospectively analyzed 10 consecutive patients with cryptococcal meningitis who were refractory to systemic administration of antifungal drugs. Results Fever or nausea occurred in most patients. However, no patient complained of serious complications such as renal toxicity. Seven patients recovered completely or partially, whereas three patients died. Conclusions To establish the efficacy of the intraventricular infusion of antifungal drugs through Ommaya reservoirs for cryptococcal meningitis, a prospective investigation should be designed to compare those treated according to the updated guidelines and those treated with antifungal drugs through the Ommaya reservoirs. |
| Databáze: | OpenAIRE |
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