Association of theMCP-1−2518 A/G Polymorphism and No Association of Its ReceptorCCR2−64 V/I Polymorphism with Lupus Nephritis
| Autor: | Viktoria Woronik, Jose Mauro Vieira, José Eduardo Krieger, Rui Toledo Barros, Alexandre C. Pereira, Patricia Malafronte |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Genotype Receptors CCR2 Immunology Lupus nephritis Renal function Kidney Kidney Function Tests Polymerase Chain Reaction Polymorphism Single Nucleotide Severity of Illness Index Statistics Nonparametric Rheumatology medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Genotyping Alleles Chemokine CCL2 Genetic Association Studies Analysis of Variance business.industry Patient Selection Middle Aged medicine.disease Lupus Nephritis Creatinine Female Gene polymorphism business Nephritis Kidney disease |
| Zdroj: | The Journal of Rheumatology. 37:776-782 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.090681 |
| Popis: | Objective.To evaluate whether the A/G polymorphism at position −2518 in the regulatory region of the monocyte chemoattractant protein-1 (MCP-1) or the V/I polymorphism at position −64 of the receptor, CCR2, are associated with lupus nephritis (LN) or any clinical characteristics of the disease or with renal survival in a patient population.Methods.We selected 197 patients with lupus nephritis and 220 matched healthy controls for study.MCP-1andCCR2genotyping was performed by polymerase chain reaction. Clinical and laboratory data were compiled from patients’ charts over followup that ranged from 6 months to 10 years.Results.The G/G genotype ofMCP-1was more common in LN patients (p = 0.019), while the A allele was associated with healthy controls (p = 0.007) as was the V allele ofCCR2(p = 0.046) compared to LN patients. Clinical index measures [SLE Disease Activity Index (SLEDAI)], immunological markers, renal histology, renal function at enrollment, and renal survival were not influenced by these polymorphisms. A less aggressive renal disease, measured by renal SLEDAI index, was associated with the V allele of theCCR2gene polymorphism.Conclusion.These findings support thatMCP-1−2518 G/G is associated with LN but there was no association of this genotype with renal function or renal survival. When studyingCCR2−64 V/I polymorphism we showed a positive association of the V allele with healthy controls but no association of the genotype with LN patients. |
| Databáze: | OpenAIRE |
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