Genetic organization of the Escherichia coli K10 capsule gene cluster: identification and characterization of two conserved regions in group III capsule gene clusters encoding polysaccharide transport functions
Autor: | Bradley R. Clarke, Rowan Pearce, Ian Roberts |
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Rok vydání: | 1999 |
Předmět: |
Bacterial capsule
DNA Bacterial Molecular Sequence Data Cell Surfaces Biology medicine.disease_cause Microbiology Conserved sequence Polysaccharides Gene cluster medicine Escherichia coli Bacteriophages Amino Acid Sequence Molecular Biology Gene Peptide sequence Prophage Bacterial Capsules Conserved Sequence Genetics Mutation integumentary system Base Sequence Escherichia coli Proteins Chromosome Mapping Gene Expression Regulation Bacterial Sequence Analysis DNA Chromosomes Bacterial Peptide Elongation Factors Genes Bacterial Multigene Family Trans-Activators Polysaccharide transport |
Zdroj: | Journal of bacteriology. 181(7) |
ISSN: | 0021-9193 |
Popis: | Analysis of the Escherichia coli K10 capsule gene cluster identified two regions, regions 1 and 3, conserved between different group III capsule gene clusters. Region 1 encodes homologues of KpsD, KpsM, KpsT, and KpsE proteins, and region 3 encodes homologues of the KpsC and KpsS proteins. An rfaH mutation abolished K10 capsule production, suggesting that expression of the K10 capsule was regulated by RfaH in a manner analogous to group II capsule gene clusters. An IS 3 element and a φR73-like prophage, both of which may have played a role in the acquisition of group III capsule gene clusters, were detected flanking the K10 capsule genes. |
Databáze: | OpenAIRE |
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