Noble metal sensitized invasive porous bioelectrodes: advanced medical device for enhanced neuronal activity and chronic alcohol treatment
| Autor: | Mi Seon Kim, Abdul Razzaq, Hansaem Choi, Su-Il In, Bong Hyo Lee, Danbi Ahn, Young Seob Gwak, Monica Claire Flores, Ogan Gurel, Hong Soo Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Medical device
Chemistry General Chemical Engineering 02 engineering and technology General Chemistry engineering.material 021001 nanoscience & nanotechnology Chronic alcohol 03 medical and health sciences 0302 clinical medicine Animal model Chronic alcoholism engineering Effective treatment Premovement neuronal activity High surface area Noble metal 0210 nano-technology 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | RSC advances. 10(71) |
| ISSN: | 2046-2069 |
| Popis: | Invasive bioelectrodes are widely used as an effective treatment for several acute and chronic diseases. In earlier work using high surface area invasive porous bioelectrodes evaluated in an animal model of alcoholism withdrawal, we demonstrated significantly improved electrophysiological and behavioral responses. In this study, we further modify the surface of these invasive porous bioelectrodes with noble metal (Ag, Au, Pt) nanoparticles. Compared to both conventional and porous bioelectrodes, noble metal sensitized invasive porous bioelectrodes show markedly increased low threshold (LT) and wide dynamic range (WDR) neuronal activity. In particular, Pt-sensitized invasive porous bioelectrodes show the highest WDR neuronal activity only upon insertion. In addition, Ag-sensitized invasive porous bioelectrodes, whose surface area is about 37 times greater than that of conventional bioelectrodes, show improved electrochemical properties with higher LT and WDR neuronal activity when stimulated. In an animal model of chronic alcoholism, using normal and alcohol-treated Sprague-Dawley (SD) rats evaluated with the elevated plus maze (EPM) test, the Ag-sensitized invasive porous bioelectrodes show about 20% higher open arms time. These results suggest that these noble metal-sensitized invasive bioelectrodes may offer improved therapeutic outcomes for the treatment of chronic alcoholism, and given these enhanced electrophysiological properties, for other conditions as well. |
| Databáze: | OpenAIRE |
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