Detection of SARS-CoV-2 N501Y mutation among SARS-CoV-2 variants of concern circulating in Northern Cyprus
| Autor: | Gulten Tuncel, Mahmut Cerkez Ergoren, Buket Baddal, Pinar Tulay, Cenk Serhan Ozverel, Emrah Guler, Huseyin Kaya Suer, Murat Sayan, Tamer Sanlidag |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Future Virology. 17:523-528 |
| ISSN: | 1746-0808 1746-0794 |
| DOI: | 10.2217/fvl-2021-0273 |
| Popis: | Aim: SARS-CoV-2 variants of concern (VOCs) carry signature mutations particularly in the spike protein. Most VOCs lineages that carry N501Y substitution have been reported to evade viral diagnostic tests and have impact on vaccine effectiveness. Therefore, monitoring the circulating variants represents a major requirement for a public health response worldwide. We aimed to investigate the prevalence of N501Y bearing SARS-CoV-2 samples in Northern Cyprus. Materials & methods: Reverse transcription quantitative PCR technique was used to identify N501Y mutation from 658 samples. Results: Our results indicate that the proportion of N501Y-bearing lineages increased significantly from January through May 2021 (45.2–75.5%) in the region. Conclusion: These results indicate that VOCs are dominant lineages in the country and highlight an alarming situation which require strict governmental measures to minimize COVID-19 morbidity and mortality. |
| Databáze: | OpenAIRE |
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