A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders
| Autor: | Carl Wolfgang Schøyen Pintzka, Daniel Kondziella, Morten Schou, Eiliv Brenner, Martin Syvertsen Mykland, Arne E. Vaaler, Ole Kristian Drange, Live Eikenes, Joan Vidal Crespi, Trond Sand, Asta Håberg, Sverre Georg Sæther |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Autoimmune diseases lcsh:Medicine Nerve Tissue Proteins Electroencephalography Receptors N-Methyl-D-Aspartate Article 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Hostility Psychoticism medicine Humans Clinical significance Prospective Studies Psychiatry Prospective cohort study lcsh:Science Psychomotor Agitation Depression (differential diagnoses) Aged Autoantibodies Multidisciplinary medicine.diagnostic_test biology Depression Glutamate Decarboxylase business.industry Mental Disorders lcsh:R Membrane Proteins Middle Aged Psychosis 030227 psychiatry Aggression Acute Disease Cohort biology.protein Female lcsh:Q Antibody business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2019) Scientific Reports Schou, M B, Sæther, S G, Drange, O K, Brenner, E, Crespi, J, Eikenes, L, Mykland, M S, Pintzka, C, Håberg, A K, Sand, T, Vaaler, A & Kondziella, D 2020, ' A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders ', Scientific Reports, vol. 10, no. 1, 35 . https://doi.org/10.1038/s41598-019-56934-6 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-56934-6 |
| Popis: | The clinical significance of anti-neuronal antibodies for psychiatric disorders is controversial. We investigated if a positive anti-neuronal antibody status at admission to acute psychiatric inpatient care was associated with a more severe neuropsychiatric phenotype and more frequent abnormalities during clinical work-up three years later. Patients admitted to acute psychiatric inpatient care who tested positive for N-methyl-D-aspartate receptor (NMDAR), contactin-associated protein 2 (CASPR2) and/or glutamic acid decarboxylase 65 (GAD65) antibodies (n = 24) were age – and sex matched with antibody-negative patients (1:2) from the same cohort (n = 48). All patients were invited to follow-up including psychometric testing (e.g. Symptom Checklist-90-Revised), serum and cerebrospinal fluid (CSF) sampling, EEG and 3 T brain MRI. Twelve antibody-positive (ab+) and 26 antibody-negative (ab−) patients consented to follow-up. Ab+ patients had more severe symptoms of depression (p = 0.03), psychoticism (p = 0.04) and agitation (p = 0.001) compared to ab− patients. There were no differences in CSF analysis (n = 6 ab+/12 ab−), EEG (n = 7 ab+/19 ab−) or brain MRI (n = 7 ab+/17 ab−) between the groups. In conclusion, anti-neuronal ab+ status during index admission was associated with more severe symptoms of depression, psychoticism and agitation at three-year follow-up. This supports the hypothesis that anti-neuronal antibodies may be of clinical significance in a subgroup of psychiatric patients. |
| Databáze: | OpenAIRE |
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