INTRAPERITONEAL SENSITIZATION AND THE TRANSPLANTED MOUSE HEART
| Autor: | G Hisatake, Ernst J. Eichwald, K Bishop, Yuanlin Shao, John J. Sullivan, Jane Shelby |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty Ratón medicine.medical_treatment Mice Inbred Strains Spleen Immunotherapy Adoptive Andrology Mice Immune system Antigen medicine Animals Germ-Free Life Sensitization Heart transplantation Mice Inbred BALB C Transplantation business.industry Spleen transplantation Graft Survival Immunotherapy medicine.anatomical_structure Heart Transplantation business Injections Intraperitoneal |
| Zdroj: | Transplantation. 51:858-861 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199104000-00023 |
| Popis: | Intradermal or skin-graft sensitization always results in accelerated rejection of subsequent MHC-disparate mouse heart transplants; intravenous or intrasplenic sensitization almost always results in prolonged survival. The survival time after intraperitoneal sensitization is unpredictable: hyperacute or accelerated rejection, as well as normal or prolonged survival, occurs suggestive of a delicate balance between suppressive and rejecting immune responses. We have observed a positive correlation between transplant survival and the distribution of 51Cr-labeled antigenic cells early after i.v., i.d., i.p., and intrasplenic injection. Label recovery from the viscera was already high 2 hr after i.v. injection, while after i.d. injection virtually all label was still confined to the carcass, even at the end of a 24-hr period. After i.p. injection label recovery varied significantly from mouse to mouse, from very low to a level approximating that seen after i.v. injection. This close correlation suggests that the fate of a subsequent transplant is decided within a few hours after antigen deposition, well before placement of the transplant itself. |
| Databáze: | OpenAIRE |
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