Determination of Oenothein B as the Active 5-α-Reductase-Inhibiting Principle of the Folk Medicine Epilobium parviflorum

Autor:	D. Lesuisse, J. Berjonneau, C. Ciot, P. Devaux, B. Doucet, J. F. Gourvest, B. Khemis, C. Lang, R. Legrand, M. Lowinski, P. Maquin, A. Parent, B. Schoot, G. Teutsch, H. Chodounská, A. Kasal
Rok vydání:	1996
Předmět:	Male Stereochemistry Hydrolyzable Tannin Pharmaceutical Science In Vitro Techniques Pharmacognosy Analytical Chemistry 5-alpha Reductase Inhibitors Drug Discovery Humans Enzyme Inhibitors Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification Plants Medicinal biology Traditional medicine Organic Chemistry Prostate Assay Biological activity biology.organism_classification Hydrolyzable Tannins Enzyme Complementary and alternative medicine chemistry Polyphenol Enzyme inhibitor Austria biology.protein Molecular Medicine Spectrophotometry Ultraviolet Tannins Epilobium parviflorum
Zdroj:	Journal of Natural Products. 59:490-492
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np960231c
Popis:	Several extracts from Epilobium parviflorum, a plant used in Central Europe for the treatment of prostate disorders, were evaluated in a biochemical assay with 5-alpha-reductase. The aqueous extract displaying inhibition of the enzyme was analyzed, the fraction responsible for this activity was purified, and the active compound identified as a macrocyclic tannin, oenothein B (1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d117cc81908e95c0fb04addab30da1a https://doi.org/10.1021/np960231c Zobrazit plný text záznamu