Alterations in expression of senescence marker protein-30 gene by 3,3′,5-triiodo-l-thyronine (T3)
| Autor: | Pranati Sar, Gagan B.N. Chainy, Bandita Rath, Prakash C. Supakar, Umakanta Subudhi |
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| Rok vydání: | 2007 |
| Předmět: |
Senescence
medicine.medical_specialty Blotting Western Clinical Biochemistry Biology medicine.disease_cause Hyperthyroidism Western blot Internal medicine Gene expression medicine Animals Rats Wistar Molecular Biology chemistry.chemical_classification Reactive oxygen species medicine.diagnostic_test Thyroid Gene Expression Regulation Developmental Cell Biology General Medicine Rats Endocrinology medicine.anatomical_structure chemistry Cytoplasm Triiodothyronine Female Sulfotransferases Oxidative stress Hormone |
| Zdroj: | Molecular and Cellular Biochemistry. 303:239-242 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-007-9462-1 |
| Popis: | Thyroid hormone (T3) is essential for normal development, differentiation, and metabolic balance of the body. A toxic dose of T(3) in animals increases the basal metabolic rate and reactive oxygen species production, resulting more oxidative stress through Ca(2+) influx to cytoplasm. Senescence Marker Protein-30 (SMP30) is preferentially expressed in the liver and protects cells against various injuries by enhancement of Ca(2+) efflux to either extra cellular space or intraorganellar spaces through membrane Ca(2+) pump activity. In this paper we report an alteration in the level of SMP30 gene expression using RT-PCR and western blot analysis in T(3) treated female Wistar rats. The results indicate that there is an induction of SMP30 expression during early hours of T(3 )treatment and it declines in severe hyperthyroidism. Therefore, we speculate that SMP30 is regulated by T(3) and might play a protective role in hyperthyroidism. |
| Databáze: | OpenAIRE |
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