Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene: Effects of rhIGFmi therapy
| Autor: | Katie A. Woods, Martin O. Savage, Adrian J. L. Clark, Farideh Miraki-Moud, Cecilia Camacho-Hübner |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty INSULIN-LIKE GROWTH FACTOR I DEFICIENCY Fetal Growth Retardation Adolescent GH Receptor Endocrinology Diabetes and Metabolism Growth factor medicine.medical_treatment Insulin Regulator Biology Phenotype Recombinant Proteins Endocrinology Internal medicine medicine Humans Insulin-Like Growth Factor I Linear growth Gene Growth Disorders Sequence Deletion |
| Zdroj: | Growth Hormone & IGF Research. 9:47-52 |
| ISSN: | 1096-6374 |
| DOI: | 10.1016/s1096-6374(99)80081-1 |
| Popis: | Insulin-like growth factor-I (IGF-I) is one of the most important regulator of growth. IGF-I deficiency is associated with prenatal and post-natal growth failure and may arise primarily as a result of GH receptor/post-receptor abnormalities or defects in the synthesis and transport of IGF-I. We have previously reported a 17.2-year-old boy with severe growth retardation and undetectable serum levels of IGF-I caused by a partial deletion of the IGF-I gene. This short review will concentrate on results of a recent study which examined the effects of rhIGF-I therapy on the GH-IGF system of this patient. Similar to healthy individuals, this patient had normal IGFBP-3 but elevated ALS levels. IGF-I treatment has improved linear growth and insulin sensitivity in this patient by restoring IGF-I levels and by normalizing circulating GH, IGFBPs and insulin levels. |
| Databáze: | OpenAIRE |
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