Associations between Serum Selenium and Total Plasma Homocysteine during the Acute Phase of Ischaemic Stroke
| Autor: | Nedka T. Chalakova, Evgeniya A. Angelova, Penka A. Atanassova, Borislav D. Dimitrov |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Total plasma Homocysteine Total homocysteine business.industry Hyperhomocysteinemia Middle Aged Serum selenium Stroke Plasma Selenium chemistry.chemical_compound Endocrinology Neurology chemistry Internal medicine Ischaemic stroke Plasma homocysteine Humans Medicine Female Neurology (clinical) business |
| Zdroj: | European Neurology. 60:298-303 |
| ISSN: | 1421-9913 0014-3022 |
| Popis: | Background/Aims: Risk of ischaemic stroke (IS) was associated with total homocysteine (tHCY). On the other hand, serum selenium (Se) exhibited anti-aging and cardiopreventive effects. Se and tHCY showed relationships in animals but these were contradictory or inconclusive in humans; therefore, we searched for such associations in acute IS. Methods: Ninety-four participants aged around 47 years were identified and 39 patients versus 46 healthy controls were analysed. Clinical, laboratory (blinded) and risk factor questionnaire methods were used. Comparison, correlation and multifactorial regression analyses were applied. Results: IS patients were similar to controls concerning age and gender. IS was prevalent in the carotid system (76.9%); 82.1% had a subacute onset. IS patients expressed higher tHCY (14.65 ± 9.79 µmol/l) and lower Se levels (1.3 ± 0.5 µmol/l). Twice as many IS patients (23%) had optimal Se levels of 6, fibrinogen, triglycerides). Conclusions: Lower Se was observed during acute IS, being inversely associated with and predicting increased tHCY levels. Of note, there were more IS patients with suboptimal Se than controls. |
| Databáze: | OpenAIRE |
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