Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway
| Autor: | Stephan L. Brown, Konjeti R. Sekhar, Girish Rachakonda, Michael L. Freeman, Soumya Sasi |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Operator (biology) NF-E2-Related Factor 2 Response element Activating transcription factor Biology Response Elements Transfection environment and public health Antioxidants Mice Sp3 transcription factor Stress Physiological Serum response factor Animals RNA Small Interfering Transcription factor Cells Cultured Activating Transcription Factor 3 Promoter respiratory system Molecular biology Activating transcription factor 2 Cell biology Repressor Proteins Gene Expression Regulation Oncology biology.protein Protein Binding Signal Transduction |
| Zdroj: | Cancer Research. 68:364-368 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-07-2170 |
| Popis: | The transcription factor nuclear factor erythroid-derived 2–related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway. [Cancer Res 2008;68(2):364–8] |
| Databáze: | OpenAIRE |
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