Increased GLP-1 response to oral glucose in pre-pubertal obese children
| Autor: | Nella Polidori, Nicoletta Pietropaoli, Francesco Chiarelli, Cosimo Giannini, M. L. Marcovecchio, Angelika Mohn |
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| Přispěvatelé: | Marcovecchio, Loredana [0000-0002-4415-316X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty gut hormones Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Incretins 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Glucagon-Like Peptide 1 Internal medicine Diabetes mellitus medicine Humans 030212 general & internal medicine Obesity Child Glucose tolerance test diabetes medicine.diagnostic_test business.industry Insulin Puberty Area under the curve Glucose Tolerance Test medicine.disease Prognosis Glucagon-like peptide-1 Glucose Case-Control Studies Pediatrics Perinatology and Child Health GLP-1 obesity Biomarkers Female Follow-Up Studies business Hormone |
| DOI: | 10.17863/cam.25978 |
| Popis: | Background: Gastrointestinal hormones, such as glucagon-like peptide (GLP-1), have been hypothesized to play a role in the pathogenesis of obesity-related complications. However, few data are available in youth. The objective of this study was to investigate the GLP-1 response to oral glucose load in obese pre-pubertal children and its relationship with insulin secretion. Methods: Ten pre-pubertal obese children [five boys; 10.5±1.6 years; body mass index-standard deviation score (BMI-SDS): 2.2±0.5] and 10 controls (eight boys; 9.9±1.2 years; BMI-SDS: –0.7±0.5) underwent a modified oral glucose tolerance test (OGTT) to evaluate post-load glucose, insulin and GLP-1 responses. Insulin sensitivity [homeostasis model assessment of insulin resistance (HOMA-IR), whole body insulin sensitivity index (WBISI)] and secretion [HOMA-beta, insulinogenic index (IGI)] indexes, area under the curve (AUC) for glucose, insulin and GLP-1 were calculated. Results: In obese children GLP-1 AUC values were higher and correlated with BMI-SDS (r=0.45; p=0.04), HOMA-IR (r=0.53; p=0.01) and fasting glucose (r=0.68; p=0.001). Conclusions: Obese children showed an increased GLP-1 response to oral glucose. These changes might likely represent a compensatory mechanism to avoid post-prandial hyperglycemia and allow a normal glucose tolerance. |
| Databáze: | OpenAIRE |
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