Thirty-year population-based review of childhood renal tumours with an assessment of prognostic features including tumour DNA characteristics
| Autor: | K.R. Muir, Jillian R. Mann, A. H. Cameron, C. E. Toyn, Henry B Marsden, J. C. Barrantes, F. Raafat, S. E. Parkes |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Adolescent Proliferative index medicine.medical_treatment Wilms Tumor Actuarial Analysis medicine Humans Stage (cooking) Child Survival analysis Univariate analysis Ploidies business.industry Incidence Incidence (epidemiology) Infant Newborn Infant DNA Neoplasm Flow Cytometry Prognosis medicine.disease Survival Analysis Kidney Neoplasms Nephrectomy Surgery Radiation therapy England Oncology Child Preschool Pediatrics Perinatology and Child Health Female Clear-cell sarcoma Radiology business |
| Zdroj: | Medical and Pediatric Oncology. 21:24-30 |
| ISSN: | 1096-911X 0098-1532 |
| Popis: | We have reviewed all paediatric kidney tumours seen in the West Midlands Health Authority Region over a 30-year period. There were 205 cases confirmed after a review of the pathology by three paediatric pathologists. Seven were cases of bone metastasising renal tumour (clear cell sarcoma), 5 were rhabdoid tumours, 2 were renal cell carcinomas, and 13 were mesoblastic nephromas. In 3 cases, it was not possible to define further the histological diagnosis. The remaining 175 cases were considered to be Wilms' tumour (86%), which is equivalent to an incidence of 5.7/10(6)/year. In the cases of Wilms' tumour, there were 91 boys and 84 girls (1.1:1). The majority of patients were Caucasian with only 7% of non-Caucasian origin. At presentation, 78% of the patients were less than 5 years old. All of these patients except 9 had surgery as part of their treatment, 154 children had total nephrectomy, 3 had partial nephrectomy, and 9 had other surgical procedures. The majority also received chemotherapy and radiotherapy. Sex, chemotherapy, and stage all had prognostic significance in univariate analysis. The actuarial survival at 10 years increased from 17% for patients treated in the first decade of the study to 78% for patients treated in the third. DNA characteristics were investigated using flow cytometry in paraffin-embedded material and adequate information was obtained in 73 cases of Wilms' tumour. Only 7 had aneuploid tumours. Univariate survival analysis of these 73 results showed that stage, sex, the percentage of cells in the synthetic phase and the proliferative index from the DNA investigations had predictive value. |
| Databáze: | OpenAIRE |
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