Bone Fractures in Children and Young Adults With Type 1 Diabetes: Age Distribution, Fracture Location, and the Role of Glycemic Control
| Autor: | Donald Wurm, Oliver Semler, Thomas Hörtenhuber, Reinhard W. Holl, Alexander J. Eckert, Dirk Schnabel, Susanne Bechtold-Dalla Pozza, Katja Schaaf, Katharina Köstner, Johanna Hammersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Glycemic Control Hypoglycemia Fractures Bone Young Adult Age Distribution medicine Humans Orthopedics and Sports Medicine ddc:610 Young adult Risk factor education Child Glycemic Glycated Hemoglobin Type 1 diabetes education.field_of_study business.industry Odds ratio medicine.disease Confidence interval Diabetes Mellitus Type 1 Female business |
| Popis: | Type 1 diabetes (T1D) is a known risk factor for fractures, but the underlying pathophysiology is still not fully understood. This study aims to define age peaks and frequent fracture sites of children and young adults with T1D. Additionally, associations of fractures with metabolic and lifestyle factors as well as with additional complications in individuals with T1D were analyzed. A total of 750 individuals with T1D aged ≤25 years with fractures were matched to 3750 patients with T1D without fractures by demographics and insulin regimen. Hemoglobin A1c (HbA1c) values were compared using linear regression, and logistic regression was used to calculate odds ratios (OR) for fractures in individuals with acute complications and diseases. Median (Q1–Q3) age was 12.7 (9.9 to 14.9) years in individuals with fractures and 16.3 (12.6 to 17.8) years in the entire control group with 65% versus 53% males. Peak age for fractures was 7 to |
| Databáze: | OpenAIRE |
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