Pregnancies after oocyte donation in women with ovarian failure caused by an inactivating mutation in the follicle stimulating hormone receptor
| Autor: | Kaisa Juntunen, Tuija Foudila, Outi Hovatta, Viveca Söderström-Anttila, Kristiina Aittomäki, Aila Tiitinen, Leena Tuomivaara |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Infertility endocrine system medicine.medical_specialty Twins Primary Ovarian Insufficiency Biology Miscarriage Follicle-stimulating hormone Pregnancy medicine Humans Point Mutation Finland Gynecology Oocyte Donation Obstetrics Rehabilitation Pregnancy Outcome Obstetrics and Gynecology Middle Aged Embryo Transfer medicine.disease Embryo transfer Reproductive Medicine Primary Ovarian Failure Receptors FSH Gestation Female Follicle-stimulating hormone receptor Infertility Female |
| Zdroj: | Human Reproduction. 17:124-127 |
| ISSN: | 1460-2350 |
| DOI: | 10.1093/humrep/17.1.124 |
| Popis: | BACKGROUND: An inactivating point mutation (Alal89Val) in the FSH receptor (FSHR) causes primary ovarian failure. It has not been known if FSH action is necessary during pregnancy and childbirth. METHODS: In 1991-2001, donated oocytes were used to treat the infertility of 12 women with ovarian failure due to this mutation. RESULTS: When 30 fresh and 15 frozen-thawed embryo transfers were performed, 14 clinical and two biochemical pregnancies resulted. To date, 12 children have been born to eight women, while one pregnancy ended in miscarriage. Three women had twin pregnancies, and one woman has delivered twice. Additionally, there are three ongoing pregnancies, of which two are second pregnancies of women who previously had a normal delivery after similar treatment. In all, 10 out of the 12 women became pregnant. Two deliveries were by Caesarean section. The rate of complications was comparable with that in pregnancies resulting from oocyte donation in general. CONCLUSIONS: Achieving and undergoing a successful pregnancy is possible when FSH action is severely decreased. Oocyte donation is an effective infertility treatment for women with FSHR mutations. |
| Databáze: | OpenAIRE |
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