Transcutaneous immunization: a human vaccine delivery strategy using a patch
| Autor: | Gregory M. Glenn, Sarah Schlesinger Frankel, Andrew D. Montemarano, Carl R. Alving, Xiuru Li, David N. Taylor |
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| Rok vydání: | 2000 |
| Předmět: |
Escherichia coli Proteins
business.industry Administration Topical Bacterial Toxins Vaccination General Medicine Vaccine delivery Enterotoxin Vaccine antigen Administration Cutaneous General Biochemistry Genetics and Molecular Biology Enterotoxins Immunization Immunology Bacterial Vaccines Escherichia coli Medicine Humans Mucosal antibodies business |
| Zdroj: | Nature medicine. 6(12) |
| ISSN: | 1078-8956 |
| Popis: | Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this simple technique induces robust systemic and mucosal antibodies against vaccine antigens. Here, we demonstrate safe application of a patch containing heat-labile enterotoxin (LT, derived from Escherichia coli) to humans, resulting in robust LT-antibody responses. These findings indicate that TCI is feasible for human immunization, and suggest that TCI may enhance efficacy as well as improve vaccine delivery. |
| Databáze: | OpenAIRE |
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