| Autor: |
Natasha Saviuk, Yumaine Chong, Peng Wang, Sara Bermudez, Zhe Zhao, Arjun A. Bhaskaran, Derek Bowie, Nahum Sonenberg, Ellis Cooper, A. Pejmun Haghighi |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cell reports. 39(10) |
| ISSN: |
2211-1247 |
| Popis: |
Genetic perturbances in translational regulation result in defects in cerebellar motor learning; however, little is known about the role of translational mechanisms in the regulation of cerebellar plasticity. We show that genetic removal of 4E-BP, a translational suppressor and target of mammalian target of rapamycin complex 1, results in a striking change in cerebellar synaptic plasticity. We find that cerebellar long-term depression (LTD) at parallel fiber-Purkinje cell synapses is converted to long-term potentiation in 4E-BP knockout mice. Biochemical and pharmacological experiments suggest that increased phosphatase activity largely accounts for the defects in LTD. Our results point to a model in which translational regulation through the action of 4E-BP plays a critical role in establishing the appropriate kinase/phosphatase balance required for normal synaptic plasticity in the cerebellum. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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