Barriers to Translating Emerging Genetic Research on Smoking into Clinical Practice: Perspectives of Primary Care Physicians
| Autor: | Caryn Lerman, Douglas Currivan, Catherine Comstock, David Blumenthal, Kevin B. Weiss, Alexandra E. Shields |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Genetic Research Attitude of Health Personnel medicine.medical_treatment Alternative medicine Primary care medicine Internal Medicine Humans Preventable death Psychiatry Primary Health Care business.industry Public health Smoking Evidence-based medicine Original Articles Clinical Practice Family medicine Smoking treatment Smoking cessation Female Smoking Cessation business Family Practice |
| Popis: | Smoking remains the leading cause of preventable death nationally. Emerging research may lead to improved smoking cessation treatment options, including tailoring treatment by genotype. Our objective was to assess primary care physicians' attitudes toward new genetic-based approaches to smoking treatment.A 2002 national survey of primary care physicians. Respondents were randomly assigned a survey including 1 of 2 scenarios: a scenario in which a new test to tailor smoking treatment was described as a "genetic" test or one in which the new test was described as a "serum protein" test.The study sample was randomly drawn from all U.S. primary care physicians in the American Medical Association Masterfile (e.g., those with a primary specialty of internal medicine, family practice, or general practice). Of 2,000 sampled physicians, 1,120 responded, yielding a response rate of 62.3%.Controlling for physician and practice characteristics, describing a new test as "genetic" resulted in a regression-adjusted mean adoption score of 73.5, compared to a score of 82.5 for a nongenetic test, reflecting an 11% reduction in physicians' likelihood of offering such a test to their patients.Merely describing a new test to tailor smoking treatment as "genetic" poses a significant barrier to physician adoption. Considering national estimates of those who smoke on a daily basis, this 11% reduction in adoption scores would translate into 3.9 million smokers who would not be offered a new genetic-based treatment for smoking. While emerging genetic research may lead to improved smoking treatment, the potential of novel interventions will likely go unrealized unless barriers to clinical integration are addressed. |
| Databáze: | OpenAIRE |
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