Autologous stem cell transplantation in acute myocardial infarction: The ASTAMI randomized controlled trial. Intracoronary transplantation of autologous mononuclear bone marrow cells, study design and safety aspects

Autor:	Astami investigators, Svend Aakhus, Svein Solheim, Harald Arnesen, Kolbjørn Forfang, Michael Abdelnoor, Ketil Lunde
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Bone Marrow Cells Transplantation Autologous law.invention Autologous stem-cell transplantation Randomized controlled trial law Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Aged Exercise Tolerance Ejection fraction business.industry Percutaneous coronary intervention Stroke Volume Middle Aged medicine.disease Surgery Transplantation surgical procedures operative medicine.anatomical_structure Case-Control Studies Acute Disease Conventional PCI Leukocytes Mononuclear Cardiology Female Bone marrow Cardiology and Cardiovascular Medicine business Stem Cell Transplantation
Zdroj:	Scandinavian Cardiovascular Journal. 39:150-158
ISSN:	1651-2006 1401-7431
DOI:	10.1080/14017430510009131
Popis:	Intracoronary transplantation of different cell populations has been used in acute myocardial infarction (AMI) with promising results. The primary objective of the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) study is to test whether intracoronary transplantation of autologous mononuclear bone marrow cells (mBMC) improves left ventricular ejection fraction (LVEF) after anterior wall AMI.The ASTAMI study is a randomized, controlled, prospective study. One hundred patients with acute anterior wall ST-elevation myocardial infarction (STEMI) treated with acute percutaneous coronary intervention (PCI) are randomized in a 1:1 way to either intracoronary transplantation of autologous mBMC 5-8 d after PCI or to control. Left ventricular function, exercise capacity, biochemical status, functional class, quality of life and complications are validated at baseline and during a 12-month follow-up.By August 2004, out of 1004 patients with STEMI, 49 patients have been included in the study. Twenty-four patients have been randomized to intracoronary mBMC transplantation. Twenty patients had chest pain and 16 patients had ischemic ECG changes during the mBMC transplantation procedure. One patient had ventricular fibrillation 24 h after transplantation.Intracoronary transplantation of autologous mBMC in the acute phase after AMI is feasible and seems safe in the short term.
Databáze:	OpenAIRE
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