The role of postoperative adjuvant radiotherapy in local recurrence risk in medullary thyroid carcinoma
| Autor: | Jerzy Wydmanski, Dorota Syguła, Ewa Paliczka-Cieslik, Agnieszka Pawlaczek, Teresa Lisik, Zbigniew Wygoda, Józef Roskosz, Zofia Kolosza, Jolanta Krajewska, Barbara Jarzab, K. Ficek, Aleksandra Kukulska, Zbigniew Puch, Aleksandra Kropińska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Medullary cavity endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Disease Lower risk lcsh:Diseases of the endocrine glands. Clinical endocrinology Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Endocrinology Median follow-up medullary thyroid carcinoma Internal Medicine medicine Lymph node Adjuvant radiotherapy lcsh:RC648-665 business.industry postoperative radiotherapy Radiation therapy medicine.anatomical_structure 030220 oncology & carcinogenesis radiation treatment Radiology business adjuvant radiotherapy |
| Zdroj: | Endocrine Connections, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2049-3614 |
| Popis: | The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in response to radiotherapy between hereditary and sporadic MTC. Methods A retrospective analysis involved 254 MTC patients, among them 73 patients with a hereditary disease. Two hundred and twenty-four patients, including 43 persons at a high risk of local relapse, underwent only initial surgery; 18 other patients were operated due to MTC recurrences, whereas the remaining 12 patients had cytoreductive procedure or were not amenable for surgery. Radiotherapy was carried out in 132 patients. One hundred and twenty patients underwent adjuvant radiotherapy, among them 102 patients after initial surgery. The median follow-up was 10 years (range 0.5–29 years). Results Local recurrence occurred in 107/254 patients, among them in 63 subjects after prior radiotherapy. The frequency of relapse showed significantly increasing trend toward higher MTC stages (P Conclusions Adjuvant radiotherapy has a limited importance in MTC treatment. It should be considered in high-risk MTC patients. The presence of RET mutation does not influence the response to radiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|