BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review
| Autor: | M. Belén Ballatore, Augusto C. Tomé, Andrés M. Durantini, Maximiliano L. Agazzi, Edgardo N. Durantini |
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| Rok vydání: | 2019 |
| Předmět: |
Alternative methods
Antimicrobial photodynamic therapy Chemistry Otras Ciencias Químicas medicine.medical_treatment Organic Chemistry Ciencias Químicas Photosensitizer Photodynamic therapy Antimicrobial Combinatorial chemistry Catalysis Antitumoral photodynamic therapy BODIPY Biological media medicine Physical and Theoretical Chemistry Photokilling CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Journal of Photochemistry and Photobiology C: Photochemistry Reviews. 40:21-48 |
| ISSN: | 1389-5567 |
| DOI: | 10.1016/j.jphotochemrev.2019.04.001 |
| Popis: | Nowadays, both cancer and infections caused by antibiotic resistant microorganisms are problems that affect the entire planet. Phototherapy (namely photodynamic therapy (PDT) and photodynamic inactivation (PDI) of microorganisms) are an alternative method for the treatment of these diseases. That requires adequate photosensitizers and, in this sense, boron-dipyrromethenes (BODIPYs) have interesting properties to act as phototherapeutic agents. In the present review, first, we describe the different strategies used to increase reactive oxygen species production. Then, we explain different architectures developed aiming to enhance the solubility of BODIPYs in biological media in order to optimize their targeting and delivery into the cells to be treated. Finally, we discuss the design of BODIPYs that are activated by specific stimuli present in the target tissues, allowing increasing the selectivity of the treatment. The data presented and discussed here show that BODIPYs are outstanding photosensitizers for the treatment of tumors and infections in the presence of oxygen and light. Fil: Agazzi, Maximiliano Luis. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ballatore, María Belén. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Durantini, Andres Matías. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tomé, Augusto C.. Universidade de Aveiro; Portugal |
| Databáze: | OpenAIRE |
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