Isotopic gas analysis by means of mid-infrared photoacoustic spectroscopy targeting human exhaled air
| Autor: | Jan C. Petersen, Jesper B. Christensen, Mikael Lassen, David Balslev-Harder |
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| Rok vydání: | 2021 |
| Předmět: |
Time delay and integration
Carbon Isotopes Materials science Spectrophotometry Infrared business.industry Analytical chemistry Biosensing Techniques Equipment Design Mass spectrometry Noise (electronics) Atomic and Molecular Physics and Optics Photoacoustic Techniques Optics Breath Tests Exhalation Attenuation coefficient Equivalent concentration Humans Isotopologue Electrical and Electronic Engineering Allan variance business Engineering (miscellaneous) Photoacoustic spectroscopy Methane |
| Zdroj: | Applied optics. 60(10) |
| ISSN: | 1539-4522 |
| Popis: | There is a great need for cost-efficient non-invasive medical diagnostic tools for analyzing humanly exhaled air. Compared to present day methods, photoacoustic spectroscopy (PAS) can provide a compact and portable (bedside), sensitive and inexpensive solution. We demonstrate a novel portable photoacoustic spectroscopic platform for isotopic measurements of methane ( C H 4 ). We identify and discriminate the 12 C H 4 - and 13 C H 4 isotopologues and determine their mixing ratio. An Allan deviation analysis shows that the noise equivalent concentration for C H 4 is 200 ppt (pmol/mol) at 100 s of integration time, corresponding to a normalized noise equivalent absorption coefficient of 5.1 × 10 − 9 W c m − 1 H z − 1 / 2 , potentially making the PAS sensor a truly disruptive instrument for bedside monitoring using isotope tracers by providing real-time metabolism data to clinical personnel. |
| Databáze: | OpenAIRE |
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