Awareness of Diagnosis in Persons with Early-Stage Alzheimer's Disease: An Observational Study in Spain

Autor: Alberto Villarejo-Galende, Elena García-Arcelay, Gerard Piñol-Ripoll, Antonio del Olmo-Rodríguez, Félix Viñuela, Mercè Boada, Emilio Franco-Macías, Almudena Ibañez de la Peña, Mario Riverol, Albert Puig-Pijoan, Pedro Abizanda-Soler, Rafael Arroyo, Miquel Baquero-Toledo, Inmaculada Feria-Vilar, Mircea Balasa, Ángel Berbel, Eloy Rodríguez-Rodríguez, Alba Vieira-Campos, Guillermo García-Ribas, Silvia Rodrigo-Herrero, Albert Lleó, Jorge Maurino
Přispěvatelé: Roche, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), European Commission, European Federation of Pharmaceutical Industries and Associations, Instituto de Salud Carlos III, Grifols, Fundación 'la Caixa'
Rok vydání: 2022
Předmět:
Zdroj: Neurology and Therapy
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Neurology And Therapy
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
ISSN: 2193-8253
Popis: [Introduction] Limited information is available on people’s experiences of living with Alzheimer’s disease (AD) at earlier stages. This study assessed awareness of diagnosis among people with early-stage AD and its impact on different person-centered outcome measures.
[Methods] We conducted an observational, cross-sectional study in 21 memory clinics in Spain. Persons aged 50–90 years, diagnosed with prodromal or mild AD (NIA/AA criteria), a Mini Mental State Examination (MMSE) score ≥ 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5 or 1.0 were recruited. The Representations and Adjustment to Dementia Index (RADIX) was used to assess participants’ beliefs about their condition and its consequences.
[Results] A total of 149 persons with early-stage AD were studied. Mean (SD) age was 72.3 (7.0) years and 50.3% were female. Mean duration of AD was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1) and 87.2% had a CDR-GS score of 0.5. Most participants (n = 84, 57.5%) used a descriptive term related to specific AD symptoms (e.g., memory difficulties) when asked what they called their condition. Participants aware of their diagnosis using the term AD (n = 66, 45.2%) were younger, had more depressive symptoms, and poorer life satisfaction and quality of life compared to those without awareness of their specific diagnosis. Practical and emotional consequences RADIX scores showed a significant negative correlation with Quality of Life in Alzheimer’s Disease score (rho = − 0.389 and − 0.413, respectively; p
[Conclusions] Awareness of diagnosis was a common phenomenon in persons with early-stage AD negatively impacting their quality of life. Understanding illness representations in earlier stages may facilitate implementing optimized care that supports improved quality of life and well-being.
This study was funded by the Medical Department of Roche Farma Spain (ML42346); funding sources with Life Molecular Imaging, Bioiberica, and Schwabe; and grants from CIBERNED, EU/EFPIA, Instituto de Salud Carlos III (ISCIII), Fundación La Caixa, and Grífols.
Databáze: OpenAIRE
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