Altered spontaneous functional activity of the right precuneus and cuneus in patients with persistent postural-perceptual dizziness
| Autor: | Lihong Si, Bin Cui, Xu Yang, Bo Shen, Kangzhi Li, Xia Ling |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Vestibular evoked myogenic potential Precuneus Audiology Dizziness 050105 experimental psychology Cuneus Perceptual Disorders 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine Parietal Lobe medicine Humans Videonystagmography 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Postural Balance Vestibular system medicine.diagnostic_test Resting state fMRI business.industry 05 social sciences Neuropsychology Brain Precentral gyrus Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Vestibular Diseases Neurology Occipital Lobe Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Brain Imaging and Behavior. 14:2176-2186 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | Persistent postural-perceptual dizziness (PPPD) is a functional vestibular disorder, and is the most common cause of chronic vestibular syndrome. However, the pathogenesis of PPPD is currently unclear. This study aimed to analyze the changes of brain spontaneous functional activities in PPPD patients during the resting state, and to explore the underlying pathogenesis of PPPD, particularly the abnormal integration of visual and vestibular information. Ten PPPD patients and 10 healthy controls were enrolled from January to June 2018, and baseline data were collected from all subjects. Videonystagmography (VNG), the vestibular caloric test, the video head impulse test (vHIT) and vestibular evoked myogenic potentials (VEMPs) were measured to exclude peripheral vestibular lesions. Functional MRI (fMRI) was conducted in PPPD patients and healthy controls. The amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo), and functional connectivity were calculated to explore changes in brain spontaneous functional activity during the resting state. Compared with healthy controls, ALFF and ReHo values in the right precuneus and cuneus were significantly lower in PPPD patients (both P |
| Databáze: | OpenAIRE |
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