The Emerging Role of Circular RNAs in Hepatocellular Carcinoma
| Autor: | Yi-Hang Wu, Liang Chen, Xiao-Feng Yu, Qi Tang, Lipeng Qiu, Keping Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
proliferation miRNA sponge Review Biology Metastasis liver cancer 03 medical and health sciences 0302 clinical medicine microRNA Gene expression medicine circRNA HCC Gene RNA medicine.disease Non-coding RNA digestive system diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research biomarker Liver cancer |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes. In this review, we concentrate on recent progress of some important circRNAs in HCC, with an emphasis on their deregulation, functions and regulatory mechanisms, and discuss their potential utility as diagnostic and/or prognostic biomarkers or therapeutic targets for HCC. |
| Databáze: | OpenAIRE |
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