Transplantation of glial cell line-derived neurotrophic factor-expressing cells into the striatum and nucleus accumbens attenuates acquisition of cocaine self-administration in rats

Autor:	Ilana Roth-Deri, Revital Geffen-Aricha, Tamar Green-Sadan, Noa Kinor, Cheryl J. Schindler, Gal Yadid
Rok vydání:	2003
Předmět:	Male medicine.medical_specialty Time Factors animal diseases Self Administration Striatum Simian virus 40 Nucleus accumbens Nucleus Accumbens Cell Line Rats Sprague-Dawley Cocaine-Related Disorders Cocaine Dopamine Uptake Inhibitors Neurotrophic factors Internal medicine Glial cell line-derived neurotrophic factor medicine Animals Humans Glial Cell Line-Derived Neurotrophic Factor Nerve Growth Factors RNA Messenger Infusion Pumps biology urogenital system business.industry Reverse Transcriptase Polymerase Chain Reaction General Neuroscience Immunohistochemistry Corpus Striatum Rats Transplantation Endocrinology medicine.anatomical_structure Nerve growth factor nervous system Gene Expression Regulation Cell culture biology.protein Neuroglia business Neuroscience
Zdroj:	The European journal of neuroscience. 18(7)
ISSN:	0953-816X
Popis:	Neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), may play a role in drug-induced biochemical and behavioural adaptations that characterize addiction. We found that GDNF mRNA levels are lower in the striatum of rats that chronically self-administered cocaine. Therefore, we examined the effect of transplanted cells used as a biodelivery system for GDNF on cocaine self-administration in rats. A human astrocyte-like cell line, which produces and excretes GDNF, was transplanted into the striatum and nucleus accumbens of rats. These rats showed a significantly lower number of active lever presses in the cocaine self-administration paradigm compared with control rats. Moreover, rats that received a chronic infusion of GDNF via a micro-osmotic pump also exhibited weak cocaine self-administration. Therefore, we conclude that exogenous augmentation of GDNF repositories may be useful in suppressing cocaine self-administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c58e33eb64080ce407ee5073b3427e9 https://pubmed.ncbi.nlm.nih.gov/14622243 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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