In vivo anti-androgenic, anti-estrogenic and antioxidant activities of the aqueous extract of Eremomastax speciosa
| Autor: | Didiane Mefokou Yemele, Richard Simo Tagne, Landry Lienou Lienou, Bruno Phelix Telefo, Nathalie Jiatsa Donfack, Armel Herve Nwabo Kamdje, Bayala Bala, Sylvain Nguedia Njina, Gildas Tetaping Mbemya, Stephanie Chekem Goka, Paul Fewou Moundipa |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Eremomastax speciosa Aqueous extract Prostate cancer lcsh:Arctic medicine. Tropical medicine Antioxidant biology lcsh:RC955-962 Chemistry medicine.medical_treatment lcsh:R lcsh:Medicine Antiandrogenic activity Pharmacology Superoxide dismutase Infectious Diseases Prostatic acid phosphatase In vivo Catalase biology.protein medicine Antiestrogenic activity hormones hormone substitutes and hormone antagonists Testosterone |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 4, Iss Sup 2, Pp 952-956 (2014) |
| ISSN: | 2222-1808 |
| DOI: | 10.1016/s2222-1808(14)60765-9 |
| Popis: | Objective: To evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic activities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against chronic diseases such as cancer. Methods: Evaluations of antiandrogenic and antioxidant activities were carried out on male rate receiving simultaneous daily administration of testosterone and different doses of aqueous extract of E. speciosa, during a period of 10 d. The evaluation of antiestrogenic activity was carried out on mature ovariectomized female rats receiving simultaneous daily administration of estradiol and different doses of extract, for a week. Then reproductive organs were weighted, levels of prostatic acid phosphatase, superoxide dismutase and catalase as well as some hematologic parameters were measured. Results: The treatment significantly reduced (P |
| Databáze: | OpenAIRE |
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