Antimicrobial photodynamic therapy as an alternative to systemic antibiotics: results from a double-blind, randomized, placebo-controlled, clinical study on type 2 diabetics
| Autor: | Umberto Demoner Ramos, Lauro Garrastazu Ayub, Sérgio Luis Scombatti de Souza, Márcio Fernando de Moraes Grisi, Daniela Bazan Palioto, Mário Taba, Danilo Maeda Reino, Arthur B. Novaes |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine 030103 biophysics medicine.medical_specialty medicine.medical_treatment Photodynamic therapy Placebo Gastroenterology Root Planing INTERLEUCINA 1 03 medical and health sciences 0302 clinical medicine Scaling and root planing Double-Blind Method Internal medicine medicine Clinical endpoint Humans Periodontal Pocket Gingival recession Doxycycline business.industry 030206 dentistry Middle Aged Antimicrobial Combined Modality Therapy Anti-Bacterial Agents Surgery Diabetes Mellitus Type 2 Photochemotherapy Dental Scaling Periodontics Female Periodontal Index medicine.symptom business Adjuvant medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0303-6979 |
| DOI: | 10.1111/jcpe.12498 |
| Popis: | Aim This double-blind, placebo-controlled clinical study compared multiple applications of the antimicrobial photodynamic therapy (aPDT) treatment protocol, to systemic doxycycline as adjuvant to scaling and root planing (SRP) on type 2 diabetic patients on clinical, systemic and immune-inflammatory outcomes. Materials and Methods Thirty patients with Hba1c >7% were allocated in two groups, SRP + Doxy (n = 15) using systemic doxycycline 100 mg/day (14 days) and SRP + aPDT (n = 15) with multiple applications (0, 3, 7 and 14 days). Primary outcome was glycated haemoglobin levels (HbA1c). Clinical parameters: plaque score (PS), bleeding on probe, probing depth, suppuration, gingival recession, and clinical attachment level, percentage of pockets with desired clinical endpoint were measured at baseline and 3 months after therapy. Cytokine profile was assessed at 0, 1 and 3 month to measure IL1-β, TNF-α and TGF-β on gingival crevicular fluid. Results No significant difference was detected on HbA1c, between treatments. The SRP + aPDT group showed advantage on reducing moderate pockets in single-rooted teeth at 3 months. SRP + aPDT presented better results at 3 months on IL1-β levels. There were no significant differences between TNF-α and TGF-β. Conclusions Both treatments improved clinical and systemic outcomes (Hba1c). SRP + aPDT performed better in moderate probing pocket depth on single-rooted teeth, reduced favourably inflammation in short term, and may be an alternative to systemic antibiotics. (Clinicaltrials.org ID NCT01595594). |
| Databáze: | OpenAIRE |
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