Myeloperoxidase gene variation and coronary flow reserve in young healthy men

Autor: Juhani Knuuti, Riikka Mäkelä, Pirjo Nuutila, Tuula Janatuinen, Reijo Laaksonen, Risto Vesalainen, Terho Lehtimäki, Olli Jaakkola
Rok vydání: 2004
Předmět:
Adult
Male
medicine.medical_specialty
Adenosine
Genotype
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
030204 cardiovascular system & hematology
Coronary artery disease
03 medical and health sciences
Coronary circulation
0302 clinical medicine
Coronary Circulation
Internal medicine
medicine
Humans
Pharmacology (medical)
Endothelial dysfunction
Promoter Regions
Genetic
Molecular Biology
Peroxidase
030304 developmental biology
2. Zero hunger
0303 health sciences
biology
business.industry
Biochemistry (medical)
Genetic Variation
Coronary flow reserve
Cell Biology
General Medicine
medicine.disease
3. Good health
Lipoproteins
LDL
Cholesterol
medicine.anatomical_structure
Endocrinology
Regional Blood Flow
030220 oncology & carcinogenesis
Myeloperoxidase
biology.protein
Cardiology
business
Oxidation-Reduction
Body mass index
Tomography
Emission-Computed
Artery
Zdroj: Journal of Biomedical Science. 11:59-64
ISSN: 1423-0127
1021-7770
DOI: 10.1007/bf02256549
Popis: Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by positron emission tomography. Myeloperoxidase (MPO) is an oxidative enzyme present in phagocytes and atherosclerotic lesions. The MPO gene has a promoter polymorphism (-463G/A) which affects gene transcription. Whether these variants associate with coronary artery function is not known. Myocardial blood flow at rest and during adenosine-induced hyperemia was assessed in 49 healthy young men with normal or slightly elevated serum total cholesterol. These subjects were divided into high (G/G) and low (A/G, A/A) MPO expression groups and effect of MPO genotype on myocardial blood flow was evaluated. We found a significant difference between MPO genotypes in CFR after adjusting for age, body mass index, smoking and family history of cardiovascular disease (p = 0.019). Men with G/G genotype had 18.1% lower CFR than subjects with low-expression genotypes (A/G and A/A). This was due to an 11.5% lower adenosine-stimulated flow of the G/G genotype carriers (p = 0.049). These findings provide evidence that MPO polymorphism is associated with coronary artery reactivity. However, the number of individuals investigated was low and our observation should be confirmed by a larger number of subjects.
Databáze: OpenAIRE
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