Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study

Autor: Asmaa Hussein Mohamed, Nelly Mohamed Said
Rok vydání: 2018
Předmět:
Adult
Male
Vascular Endothelial Growth Factor A
Colorectal cancer
medicine.medical_treatment
Adenocarcinoma
medicine.disease_cause
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Lipid biosynthesis
Biomarkers
Tumor
medicine
Humans
Aged
Retrospective Studies
Neovascularization
Pathologic
biology
business.industry
Growth factor
Gastroenterology
Middle Aged
Prognosis
medicine.disease
Adenocarcinoma
Mucinous
Fatty Acid Synthase
Type I
Vascular endothelial growth factor
Fatty acid synthase
Oncology
chemistry
Case-Control Studies
Lymphatic Metastasis
030220 oncology & carcinogenesis
biology.protein
Cancer research
Immunohistochemistry
Female
030211 gastroenterology & hepatology
Colorectal Neoplasms
business
Carcinogenesis
Carcinoma
Signet Ring Cell
Follow-Up Studies
Zdroj: Journal of Gastrointestinal Cancer. 50:485-492
ISSN: 1941-6636
1941-6628
DOI: 10.1007/s12029-018-0104-5
Popis: Fatty acid synthase (FAS) is a valuable lipid enzyme involved in lipid biosynthesis and suggested to contribute in tumor carcinogenesis. Vascular endothelial growth factor (VEGF) is considered a serious angiogenic growth factor in the angiogenic pathway which is a very important in tumor growth and metastasis. Thus, inhibition of lipid biosynthesis and tumor angiogenesis can be new goals for colorectal cancer (CRC) treatment. The assessment of the expression of FAS and VEGF protein and the relationship between them in CRC with the clinicopathological parameters. The present retrospective study included 63 paraffin blocks previously diagnosed as primary cases of CRC. The slides were subjected to FAS and VEGF immunohistochemical staining using a streptavidin-biotin-peroxidase. The relationships among FAS and VEGF expression and clinicopathological parameters were statistically analyzed. The expression rate of FAS was 81% and VEGF was 84.1% in the studied cases. FAS expression was significantly associated with histopathological type (p = 0.02) and grade (p = 0.04), and highly associated with lymph node metastasis and stage (p
Databáze: OpenAIRE
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