HLA-DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan
| Autor: | Li Chen Chen, T.-D. Lee, Tsung-Chieh Yao, Ming-Ling Kuo, C.-C. Yeh, C.-K. Shaw, Jing-Long Huang |
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| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Genotype Immunology Taiwan Arthritis Biology Gastroenterology immune system diseases Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele Child skin and connective tissue diseases HLA-DRB1 Genotyping Oligoarthritis HLA-DR Antigens Odds ratio medicine.disease Confidence interval Case-Control Studies Polyarthritis HLA-DRB1 Chains |
| Zdroj: | European Journal of Immunogenetics. 31:185-188 |
| ISSN: | 1365-2370 0960-7420 |
| Popis: | The object of this study was to investigate whether there is an association between HLA-DRB1 alleles and the development of juvenile idiopathic arthritis (JIA) in Taiwan. HLA-DRB1 alleles were studied in 60 patients with JIA and 200 healthy controls using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSO). The frequency of HLA-DRB1*0405 in patients with JIA was found to be significantly higher than that in healthy controls [odds ratio (OR) 2.64, 95% confidence interval (CI) 1.01-6.91]. The DRB1*0405 allele was significantly associated with the development of both polyarthritis (OR 4.30, 95% CI 1.34-13.80) and oligoarthritis (OR 3.27, 95% CI 1.01-10.58). The frequency of HLA-DRB1*1502 was higher in Taiwanese JIA patients with systemic arthritis than in controls (OR 18.09, 95% CI 2.25-145.73). We conclude that, in Taiwan, HLA-DRB1*0405 is associated with the development of polyarthritis and oligoarthritis in children, and HLA-DRB1*1502 is associated with the development of systemic arthritis. |
| Databáze: | OpenAIRE |
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