Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity
| Autor: | Daniel Biass, Philippe Favreau, Reto Stöcklin, Sébastien Dutertre |
|---|---|
| Přispěvatelé: | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Zoology Mollusk Venoms Intraspecimen variation Venom Snail Biology Toxicology Peptide Mapping Cone snail 03 medical and health sciences Species Specificity biology.animal Animals Conopeptide Chromatography High Pressure Liquid 030304 developmental biology 0303 health sciences Mass spectrometry 030302 biochemistry & molecular biology Conus Snail Conus consors Anatomy biology.organism_classification Highly sensitive [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Single cone |
| Zdroj: | Toxicon Toxicon, Elsevier, 2010, 55 (8), pp.1453-1462. ⟨10.1016/j.toxicon.2010.02.025⟩ |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2010.02.025⟩ |
| Popis: | International audience; With the advent of highly sensitive mass spectrometry techniques, the minute amount of various secretions produced by living animals can be studied to a level of details never attained before. In this study, we used LC-ESI-MS to analyse the injected venom of an indo-pacific piscivorous cone snail, Conus consors. While long-term follow up of several captive specimens have revealed a typical "venom fingerprint" for this species, dramatic variations were also observed. In the most extreme case, a single cone snail unexpectedly produced two very distinct venom profiles containing completely different sets of peptides with no overlap of detected masses. Surprisingly, there was no correlation between the peptides produced in the venom duct and those obtained after milking live cone snails, implying yet unknown mechanisms of selection and regulation. Our study defines the notion of intraspecimen variation and demonstrates how this phenomenon contributes to the overall venom diversity. |
| Databáze: | OpenAIRE |
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