Helminths: Immunoregulation and Inflammatory Diseases-Which Side Are Trichinella spp. and Toxocara spp. on?
| Autor: | Ljiljana Sofronic-Milosavljevic, Elena Pinelli, Carmen Aranzamendi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
Cell type Trichinella infection medicine.medical_treatment Trichinella Immunosuppression Review Article Biology biology.organism_classification lcsh:Infectious and parasitic diseases 3. Good health 03 medical and health sciences Crosstalk (biology) 0302 clinical medicine Infectious Diseases Immune system Immunopathology Immunology parasitic diseases medicine Helminths lcsh:RC109-216 Parasitology 030304 developmental biology 030215 immunology |
| Zdroj: | Journal of Parasitology Research Journal of Parasitology Research, Vol 2013 (2013) |
| ISSN: | 2090-0023 |
| Popis: | Macropathogens, such as multicellular helminths, are considered masters of immunoregulation due to their ability to escape host defense and establish chronic infections. Molecular crosstalk between the host and the parasite starts immediately after their encounter, which influences the course and development of both the innate and adaptive arms of the immune response. Helminths can modulate dendritic cells (DCs) function and induce immunosuppression which is mediated by a regulatory network that includes regulatory T (Treg) cells, regulatory B (Breg) cells, and alternatively activated macrophages (AAMs). In this way, helminths suppress and control both parasite-specific and unrelated immunopathology in the host such as Th1-mediated autoimmune and Th2-mediated allergic diseases. However, certain helminths favour the development or exacerbation of allergic responses. In this paper, the cell types that play an essential role in helminth-induced immunoregulation, the consequences for inflammatory diseases, and the contrasting effects ofToxocaraandTrichinellainfection on allergic manifestations are discussed. |
| Databáze: | OpenAIRE |
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